This is so because the enzymes in the liver that eliminate pravastatin and rosuvastatin are not blocked by many of the drugs that block the enzymes that eliminate other statins.
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Rosuvastatin works by blocking enzymes in your liver that make cholesterol.
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higher plasma concentrations of rosuvastatin have been reported in very small groups of patients n 3 to 5 who have two reduced function alleles of the gene that encodes oatp1b1 slco1b1 521t c .